Gene Having A Role In Leukemia Is Also Linked To Alzheimer’s!
A team of researchers headed by Dr. Peter Davies discovered that a molecule named c-Abl which has been shown to play a significant role in leukemia earlier, also has an active role in the development of Alzheimer’s disease.
c-Abl is a protein and a tyrosine kinase that is actively involved in cell division, differentiation and adhesion.
Dr. Davies aimed his study at this particular protein after finding it in the tangles and plaques of the crowded brains of the people suffering from Alzheimer’s.
This study was designed by him to check whether the activated c-Abl in the brain kills the adult brain cells after turning on the cell cycle and surprisingly it was found that when the cell cycle was turned on, the adult brain cells got damaged.
In the study, human c-Abl genes were turned on in the hippocampus and the neocortex regions of the adult mice. This led to excessive cell death in both the regions.
The next step of this research is to develop drugs aimed at the protein according to Dr. Davies.