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How Cancer Cells Survive the Natural Defense Mechanism

Researchers from the Dana-Farber Cancer Institute have found how the cancer cells manage to survive from the tumor suppression mechanism of the immune system.

An unknown link between signaling pathways Rb and Hippo was discovered in the study. This pathway has an essential role to play in early development of cells and tissues. In cancer patients, this pathway is disrupted.

As a part of a healthy cell’s life process, it either becomes inactive or passes on to a new state of development after a particular period of time. Technically these events are called senescence and quiescence phases.

Signals play an important role in the regulation of these events. Cancer cells ignore these signals and manage to reactivate themselves in a new phase or continue to grow abnormally without dying their natural death. How these malignant cells manage to negotiate with the signal mechanism is less understood.

The present study found a group of eight proteins called the DREAM complex, which act as the gatekeepers or molecular switches to senescence and quiescence of cancer cells.

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