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Protein That May Lead to Obesity & Diabetes Discovered!

Two researchers from Albert Einstein College of Medicine, Yeshiva University have discovered the protein in the brain that may be contributing to obesity and type 2 diabetes.

TXNIP or thioredoxin-interacting protein was found to play a key role in the onset of obesity and type 2 diabetes.

The current study was conducted on mice models. It was observed that the excess availability of nutrients increases the levels of this protein which is found in the nutrient sensing cells of hypothalamus.

The elevated protein levels may contribute to the changes in energy homeostasis, i.e., the balance between the intake of calories and the amount of calories burned.

The researcher duo found that the increased levels of TXNIP in hypothalamic nerve cells contributed to obesity by lowering the energy expenditure by decreasing the rate at which fat is burned to produce sufficient energy. The protein also impaired insulin sensitivity and glucose tolerance, the characteristic features of diabetes.

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