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New Inhibitor Molecules Discovered to Stop Wnt Pathway Activities

Aberrations in Wnt pathway has been known to the scientists as the cause of cancer development in skin, breast, liver and especially in colon. But, it was difficult until now to develop a therapeutic mechanism for addressing this issue.

Researchers from the Cancer Institute at NYU Langone Medical Center have found three molecules which can inhibit the signaling process in the Wnt pathway. The mentioned activity is vital for the development of cancer tumor and progression of the ailment.

According to the lead expert of the study, their findings can lead to the development of drugs which can effective destroy the Wnt pathway dependent malignant cells. No threat will be posed to the normal growth or existence of the healthy cells around. The molecules achieved their objective by suppressing the activities which take place in the pathway in experimental rats.

The results of their study are published in the April 12th, 2011 issue of the journal Proceedings of the National Academy of Sciences.

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