Stem Cells From Blood Vessels To Repair Teeth!
A new scientific breakthrough reveals that the stem cells found on the surface of blood vessels have the capacity to grow into organs and repair damaged tissues. This study was conducted by the researchers of King’s College London and is the first of its kind.
The research results were published in Proceedings of the National Academy of Sciences (PNAS). The funding for the research was provided by Medical Research Council (MRC).
The study was based on the activity of perivascular cells, the scattered cells in the walls of blood vessels. These cells act as the first line of response to any tissue injury or damage by increasing the flow of blood to the injured area. This activity increases their number rapidly.
Because these cells are present in several human tissues, the researchers came up with the option of using them for providing a more effective natural mechanism to repair tissues and organs.
The experiments were performed on the incisor teeth of rodents. Incisors are the sharp teeth that gain their sharpness by the continuous shearing action of their tips. In this process, the tissue is lost.
It was shown that the perivascular cells could differentiate into other types of cells when needed, just like stem cells.
When the tooth was damaged, new odontoblasts or tooth cells were produced by perivascular cells, aiding in the regeneration of the damaged tooth tissue.
According to Professor Paul Sharpe, the lead scientist of this study and a Professor in the department of craniofacial development of dental institute at King’s College, differentiation of perivascular cells into a set of specialized cells as a part of natural repair process has been studied and achieved for the first time.
He also opines that, these findings not only enable them to study the mechanism of tissue repair at cellular level, but also provide new options for dental regenerative medicine.