Role of Heparin in Causing Allergy is Identified
Researchers from the Karolinska Institutet in Sweden have discovered that a drug which prevents the clotting of the blood is closely linked to the onset of allergy in the body. The results of the study are published in the February 2011 issue of the journal Immunity.
Professor Erik Jorpes of this same institute successfully isolated these molecules of the mast cells in 1935. He used these molecules in treating clotting of the blood. The same mast cells play a pivotal role in the onset and spreading of allergy.
The present study found that the heparin is responsible for the production of a hormone known as bradykinin. This signaling molecule makes all the signs of abnormal mast cells activities to become apparent.
The release of the mentioned hormone into the blood is associated with the activation of a chemical called factor XII of the blood coagulation system.
As a part of the further research, scientists are focusing their attention on the development of drugs which can block the activities of bradykinin and factor XII in order to inhibit allergy.