Skeleton Might Play a Vital Role in Male Fertility

According to a research conducted at the Columbia University Medical Center, the skeleton can regulate the fertility in male mice. This happens through osteocalcin, a hormone which is released by the bones. The researchers carried out many experiments to show that osteocalcin might enhance the testosterone production. Testosterone is the sex steroid hormone which controls male fertility.

Gerard Karsenty, M.D., chair of the Department of Genetics and Development at Columbia University Medical Center and the lead researcher, and his team observed that the male mice whose skeletons could not secrete osteocalcin were poor breeders.When they added the hormone osteocalcin to the cells the levels of testosterone went up. Researchers also noticed that in the absence of osteocalcin the sperm count declines. When the osteocalcin-deficient male mice bred with the normal female mice, they could produce only half of the pups which the normal males were able to breed.

These findings have not been observed in human beings, the researchers expect similar outcome. This is due to the fact that there are similarities between human and mouse hormones.

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