Promising Treatment for Bone Cancer Metastasis is Discovered
In 70-80 percent cases of breast cancer, the disease spreads to the most common site bone. Researchers from the Princeton University have discovered how this mechanism of spreading takes place.
The effort has lead to the development of treatments of breast cancer. The results of the study are published in the February 3, 2011 online issue of the journal journal Cancer Cell.
The study has found a new protein Jagged1 which initiates a series of molecular events technically known as Notch signaling. The consequence of these events is that destruction of bone cells commences caused by a protein the TGF-beta protein.
These events also increase the levels of another destructive protein IL-6 which promotes the growth of tumor cells by providing the required nutrients for their proliferation.
Development of drugs which can block the activities of the protein “Jagged 1” can provide a treatment option for bone cancer metastasis. Presently, the standard treatments are inadequate in attaining this objective.