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How Sleeplessness and Type 2 Diabetes Are Related

Type 2 Diabetes is an auto-immune disorder. A person suffers from such a problem when body loses the ability to differentiate between healthy and unhealthy cells. Diabetes is a wide-spread disorder worldwide and a serious health issue for governments.

Off Late, researchers have associated this disorder with epidemic like obesity and prevalent bad habit like smoking.

Type 2 diabetes is diagnosed late often. This disorder starts affecting the body nearly 13 years prior to its diagnosis. 10 years after the diagnosis of the problem, associated complications of having such an autoimmune disorder become apparent.

Some of these associated complications for having long-term diabetes are heart diseases, blindness, depression and sleeplessness.

An international research team in January 2009 discovered the link between type 2 diabetes and sleeplessness (technically called Insomnia). German researchers at the Helmholtz Zentrum München along with other researchers, found that a gene MTNR1B plays a vital role in relating sleeplessness with diabetes.

Basic Appreciate the Research:

  • Human body is made of cells. They are the basic building blocks of life.
  • The functions of cells are regulated by a collection of chemical instructions called genes. A chromosome is a single chemical instruction.
  • A collection of cells is called a tissue and when tissues combine, an organ of the body is formed.
  • The cell is provided nourishment by naturally available chemical substances called proteins.
  • Other naturally present chemical substances like hormones and enzymes, help the cells in proper functioning of the body.
  • Humans get sleep when a hormone called melatonin is released in the body.
  • The presence of this hormone is high in the body naturally at night times. It’s levels decrease as the day breaks.
  • The glucose level in the blood is controlled by a hormone called insulin.
  • This hormone is produced by special cells called the islet cells in pancreas.
  • The level of insulin is higher at daytime and lower at the night.
  • When hormones are released in the body, a specific component of the cells called the receptors, get activated.

Knowledge Gained about the Gene MTNR1B: The research revealed that the gene MTNR1B controls the working of the insulin producing islet cells. It also affects the receptors associated with sleep hormone melatonin. The researchers believe that the receptors of sleep cells as a result of this gene’s negative influence, stop the release of hormones insulin and melatonin in the blood of diabetic patients. This causes a rise in the blood sugar level and sleeplessness in them. Further understanding of the mechanisms by which MTNR1B gene influences sleep cell receptors, is the purpose of the on-going studies on this topic.

This research finding suggests that genes start mal-functioning in a person suffering from an auto-immune disorder.

Can any one share the knowledge on this very important subject ?

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