Ways to Inhibit Maleria from Becoming Antidrug Resistant Are Found
Scientists, at a meeting of the American Society of Tropical Medicine and Hygiene, made a declaration on 19th November 2009. The declaration was that Malaria became drug resistant once again. 350 Million people world wide get affected from it every year out of which 1 Million people die. This disease has a notorious history of being drug resistant.
How Malaria Became Drug Resistant Earlier: In November 2009, the reason for Malaria to be drug resistant was partly because of the negligence of the health practitioners. A powerful anti-malerial drug called Artemisinin was capable enough of dealing with malaria to a large extent. But, the World Health Organization had set a strict guideline for given this drug along with another added drug. The added drug killed the left over bacteria too, which managed to survive the influence of Artemisinin drug. But, according to Dr. Christopher King of Case Western Reserve University in Cleveland, health practitioners from the most affected regions of the world, Asia and Africa, did not follow this important guideline. As a result, the survivor bacteria of Artemisinin drug were provided the chance to quickly multiply and make malaria drug resistant again. Researchers now report that they are close to developing a new antimalarial drug again. This time the idea to develop the drug has come from understanding how another important antimalarial drug chloroquine became drug resistant.
What Latest Research Learnt About the Disease: The bacteria which causes malaria is a single cell organism. There are some chemical substances called transporter proteins inside its cell. They normally provide protection to the cell from external stresses and make it antimalarial drug resistant. The transporter proteins successfully do so by removing the drug chloroquine from the cell. In this way, the cell survives. The research study has found that the chemical substance, transporter protein has now undergone change, and stopped functioning normally. As a result, researchers have got a chance to further their malaria research.
They have learnt that, if this transporter protein is not allowed to function normally for ever, the bacteria will die and there will be no future cases of malaria disease becoming drug resistant again. This can be achieved by inactivating the gene which controls transporter protein. Genes are natural chemical instructions which run the normal functioning of any living being. The present day medical science is adept at locating, activating and inactivating genes in organisms. The transporter protein provided protection to the malaria bacteria cell by providing