Old Antidepressant Can Prevent Heart Failure

Physical disorders like Obesity and Diabetes and bad habit like smoking are prevalent in American society. Off late, research has found preliminary indications of a dangerous nexus between these wide spread health risk factors. This can further enhance the rate of heart attacks, as all three of them (Obesity, Diabetes and Smoking) coupled with stress, rank high among the potential risk factors for heart ailments. Latest research (Dated January 2010), in this field reports that a 40 years old antidepressant, not in use any more, can prevent heart attacks. This article tries to gain further insight in the topic by chronicling in brief the findings of the research.

Knowledge Gained from Research:

  • The research study was conducted at the John Hopkins University on experimental animals.
  • Enzymes and Hormones are naturally found chemical substances in our body.
  • Hormones carry out various functions of the organs and enzymes initiate such processes by releasing hormones.
  • Proper and timely release of a hormone called Norepinephrine causes pumping of the heart in harder and faster manner, under stressful conditions, as a part of its normal functioning.
  • According to Dr.Nazareno Paolocci, Senior study investigator and Cardiologist at the John Hopkins University School of Medicine, when this hormone is not properly stored and released on time, an enzyme called Monoamine oxidase-A MOA, starts a series of harmful chemical reactions, in a heart patient’s body.
  • As a result, stress is created on the heart muscles and pumping rate of the organ increases causing heart attack.
  • Researchers found that the antidepressant Clorgyline could successfully block the enzyme monoamine oxidase-A (MOA), which in turn arrests the release of the hormone Norepinephrine.
  • This removes the excess load of performance on the heart under stressful conditions, preventing the failure of the organ.
  • The research also has shed new light on the understanding of heart attack. Doctors can now look at it as a biochemical activity.
  • Possibility of discovering more effective drugs in addressing heart attacks has thus opened up. These drugs can focus on blocking the release of Norepinephrine hormone without posing any threat from their side.
  • However, the researchers caution that though the findings are promising, the research is in its initial stages and further efforts are to be placed without any delay. Human trails of the drug is a distinct possibility still. Effectiveness of other drugs, belonging to the class of Clorgyline, and approved by United States Food and Drug Administration, is to be tested next by the researchers

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